SARS-CoV-2 H69del spike protein mutation is associated with less severe COVID-19 patient outcomes

SARS-CoV-2 H69del spike protein mutation is associated with less severe  COVID-19 patient outcomes

by Laine Bénard, Mikhail Bond, Orchee Haque, Stephanie Huynh and Molly McVean (senior author)
1st Place in the Youreka Canada National Competition

Mutations that alter the amino acid sequence of the SARS-CoV-2 coronavirus spike protein often result in structural changes that affect its transmissibility and infectivity. The objective of this study was to determine whether the presence of the H69del spike protein frameshift mutation is related to the severity of patient outcomes in individuals infected with SARS-CoV-2, as measured by the number of hospitalizations due to COVID-19.

The Effect of COVID-19 Restrictions on Opioid Overdoses in Alberta and Ontario

The Effect of COVID-19 Restrictions on Opioid Overdoses in Alberta and Ontario

by Ayah El-Hajj, Sophia Burns, Jazlyn Chan, Nabeel Khan, Justina Wong (senior author)
2nd Place in the Youreka Canada National Competition

The implementation of COVID-19 restrictions has exacerbated the existing national opioid crisis by increasing social isolation and limiting dependency program access. This study examines the impact of COVID-19 restrictions on opioid overdose rates by analyzing opioid-related mortalities and Emergency Medical Service (EMS) responses in Alberta and Ontario.

Human Development and COVID-19: An Unforeseen Positive Correlation

Human Development and COVID-19: An Unforeseen Positive Correlation

by Zenab Gill, Shreya Mulpuri, Yasmeen Jalil, Jack Ma, Kritika Taparia (senior author)
3rd Place in the Youreka Canada National Competition

The Human Development Index (HDI) is a statistic summarizing the average life expectancy, years of education, and gross national income, and is used to give a holistic measure of a nation’s human development. The association between HDI and COVID-19 has not been commonly investigated and is also contested; this lack of research and consensus in current literature compelled us to investigate the correlation between HDI, as well as its components, and COVID-19 case and fatality rates. A preliminary One-way Welch’s test (non-parametric ANOVA) was conducted to determine significant differences between HDI categories and COVID-19 case and fatality rates.

Mutations within DPP9, IFNAR2, SLC6A20, and TMPRSS2 Associated with COVID-19, But Show No Distinct Correlations With COVID-19 Severity

Mutations within DPP9, IFNAR2, SLC6A20, and TMPRSS2 Associated with COVID-19, But Show No Distinct Correlations With COVID-19 Severity

by Gabriel Orhadje, Abigail Green, Ayman Mohammed, Maitri Shah, Avery Willis

Through analysis of the discrepancies between the severity of COVID-19 outcomes in individuals, previous literature has determined that certain genes are associated with severe cases of the virus. Four of these genes are studied in this project. This study aims to conclusively determine the correlation between the allelic mutation frequencies in these genes per ethnic populations, which would likely alter their enzyme product and its interaction with the COVID-19 virus, and mortality rate (deaths per number of tests) of COVID-19.

Hidden Facts behind COVID-19

Hidden Facts behind COVID-19

by Kibo Nagasaki

There are few previous papers that consider potential relationships between SARS-CoV-2 and influenza viruses. Bert et al. (2020) comprehensively reviewed how the human immune system responds to the infection of viruses. However, to the best of my knowledge, there are no previous studies to explain the reason for the suppression of influenza patients during the COVID-19 pandemic. The original purpose of this paper was to elucidate why the number of influenza cases in Canada and Japan in 2019-2020 and 2020-2021 was suppressed compared to the past years. In addition, the new purpose was to provide a learning aid to help other students learn about how science constantly evolves.

Soaperb Sanitizer

Soaperb Sanitizer

by Khaliya Thawer

The Centers for Disease Control and Preservation (CDC) state that they “recommend washing hands with soap and water whenever possible because handwashing reduces the amounts of all types of germs and chemicals on hands.” For this experiment, the germs that accumulate on one’s hands through contaminated surfaces are transferred onto bread and mold is produced from those germs. The main question for this experiment, as well as the purpose for the following research is, how does the type of hand sanitizer/soap affect its ability to eliminate germs like mold?

La Méduse

La Méduse

by Évangeline LaForest & Oscar McClements

La Méduse (French for ‘jellyfish’) is a machine with a cool design that could help reduce the amount of trash in our oceans. Évangeline and Oscar explain what it does, how it works, and why this issue matters to them.

In collaboration with Little Inventors